Table 3.
Characteristics of subjects with and without cirrhosis by ICD‐10 codes in Mass General Brigham Biobank
| No Cirrhosis (n = 18,394) | Cirrhosis (n = 929) | Total (N = 19,323) | P Value | |
|---|---|---|---|---|
| Age (years) | 63.00 [49.00, 73.00] | 65.00 [57.00, 73.00] | 63.00 [50.00, 73.00] | <0.001 |
| Sex (male) | 8,620 (47%) | 536 (58%) | 9,156 (47%) | <0.001 |
| BMI (kg/m2) | 26.58 [23.40, 30.55] | 28.25 [24.55, 32.79] | 26.61 [23.41, 30.66] | <0.001 |
| ALT (U/L) | 22.48 [17.00, 31.25] | 35.85 [24.91, 56.85] | 23.00 [17.05, 32.36] | <0.001 |
| AST (U/L) | 24.00 [19.91, 30.09] | 40.23 [28.36, 61.44] | 24.33 [20.00, 31.00] | <0.001 |
| ALP (U/L) | 73.00 [60.43, 89.44] | 95.39 [75.06, 131.14] | 74.00 [61.00, 91.00] | <0.001 |
| Platelets (109 cells/L) | 242.90 [205.00, 285.23] | 209.31 [159.74, 259.42] | 241.45 [203.00, 284.42] | <0.001 |
| Albumin (g/dL) | 4.26 [3.99, 4.47] | 3.93 [3.57, 4.25] | 4.25 [3.97, 4.47] | <0.001 |
| FIB‐4 | 1.29 [0.90, 1.81] | 2.17 [1.39, 3.57] | 1.32 [0.92, 1.87] | <0.001 |
| LDL (mg/dL) | 97.33 [77.00, 119.00] | 88.80 [70.52, 110.71] | 97.00 [76.50, 118.50] | <0.001 |
| HDL (mg/dL) | 53.00 [43.00, 65.76] | 46.00 [37.67, 57.33] | 52.67 [42.59, 65.17] | <0.001 |
| Cholesterol (mg/dL) | 183.17 [160.32, 206.99] | 174.00 [149.75, 196.29] | 182.50 [159.50, 206.36] | <0.001 |
Median [interquartile range] or number (%) are reported. Comparisons are made using the Kruskal‐Wallis test. FIB‐4 is a noninvasive marker of hepatic fibrosis calculated by age × AST [U/L] / (PLT [109/L] × ALT1/2 [U/L]).( 30 )
Abbreviations: HDL, high‐density lipoprotein; PLT, platelet.