Table 4.
Association of genetic variants with biomarkers of liver injury in the additive (per allele) model in Mass General Brigham Biobank
| Variant | Measure (U/L) | Estimate | SE | Pr (>|t|) |
|---|---|---|---|---|
| PNPLA3 I148M | log ALT | 3.69e−02 | 8.43e−03 | 1.21e−05 |
| log AST | 2.67e−02 | 6.19e−03 | 1.61e−05 | |
| log ALP | 4.13e−03 | 6.21e−03 | 5.06e−01 | |
| TM6SF2 E167K | log ALT | 2.75e−02 | 1.38e−02 | 4.63e−02 |
| log AST | 2.15e−02 | 1.01e−02 | 3.38e−02 | |
| log ALP | −1.51e−02 | 1.02e−02 | 1.38e−01 | |
| SERPINA1 Z allele | log ALT | 8.18e−02 | 2.70e−02 | 2.44e−03 |
| log AST | 3.34e−02 | 1.99e−02 | 9.23e−02 | |
| log ALP | 7.07e−02 | 1.99e−02 | 3.74e−04 |
Linear regression was performed adjusting for age, sex, BMI, batch, and the first 10 principal components of ancestry.
Abbreviations: Pr (>|t|), P value for the proportion of the t distribution that is greater than the absolute value of the t statistic; SE, standard error.