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. 2021 Aug 3;9:697035. doi: 10.3389/fcell.2021.697035

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Copyright © 2021 Zhou, Xu, Wang, Luo, Xu, Cheng, Jin, Guo, Xue, Juan, Anashkina, Nie and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The distribution of Missense Mutations in SARS-CoV-2. A stacked histogram shows all missense mutations of SARS-CoV-2 from different continents of the world. (B) A chord diagram shows the missense mutation shared between different proteins of SARS-CoV-2, and the color scheme is the same as that in (A). (C) A topology and cartoon representation of SARS-CoV-2 homo-trimeric spike (S) glycoprotein (PDB ID: 6VSB). NTD, N-terminal domain; FP, fusion peptide; HR1, heptad repeat 1; CH, central helix; CD, connector domain; HR2, heptad repeat 1; TM, transmembrane region; CT, cytoplasmic tail; S1/S2, protease cleavage sites; Some important mutation sites and residue intervals were marked on the figure. (D) A Venn diagram of main amino acid mutation sites of the S protein, the number of mutations, and co-mutations were shown.