Figure 1.
Inactivation of the Nemo gene induces cell mitosis in cerebral vessels. (a) Transcriptional profiling of cerebral vessels of NemobeKO mice and NemoFl controls (n = 7) showed that, among the differentially expressed genes, 10.4% were involved in cell cycle/cell division/mitosis according to their functional annotations. The analysis included only transcripts with a change < −2-fold or > 2-fold and P-values (pANOVA and pFDR) <0.05. (b) Hierarchical clustering of the mitotic genes that were significantly changed in NemobeKO mice compared to control mice. (c) Representative immunostainings for Ki67 and CD31 showing proliferating cells along vessels in the cortex of NemobeKO but not NemoFl mice, at day 15 after starting tamoxifen injections. Nuclei were stained with DAPI. Scale bar, 100 μm.