Figure 4.

Scatter plots and linear regressions with 95% confidence intervals of transcranial pulse wave velocity (PWV) and age are shown for Alzheimer’s disease (AD) subjects (a), mild cognitively impaired (MCI) subjects (b), healthy controls (c), and healthy subjects with APOE4+, FH+ (d). Transcranial PWV was highest in AD subjects for all ages and displayed a slow decrease with age in AD (R² = 0.017). For MCI subjects, transcranial PWV increased slightly with age (R² = 0.009); however, for controls, transcranial PWV increased in a more linear fashion (R² = 0.305). The middle-aged APOE4+, FH+ group (d) shows higher transcranial PWV compared to controls with similar age range (R² = 0.001).