Table 1.
Demographic information.
| Total(n = 160) | AD(n = 28) | MCI(n = 34) | Older cognitively healthy (n = 42) | Middle-age APOE4+, FH+(n = 24) | Middle-ageAPOE4−, FH−(n = 32) | |
|---|---|---|---|---|---|---|
| Age (years) | 68 ± 10 | 72 ± 10 | 73 ± 9 | 73 ± 7 | 59 ± 3 | 58 ± 5 |
| Female (n, %) | 100, 63 | 17, 61 | 17, 50 | 25, 60 | 17, 71 | 24, 75 |
| Parental dementia history positive (n, %) | 54, 34 | 11, 39 | 18, 53 | 2, 5 | 24, 100 | 0, 0 |
| APOE ɛ4 carrier (n, %)* | 45, 28 | 10, 36 | 10, 29 | 1, 2 | 24, 100 | 0, 0 |
| SBP (mmHg) | 128 ± 18 | 131 ± 20 | 131 ± 17 | 132 ± 21 | 122 ± 10 | 122 ± 14 |
| DBP (mmHg) | 77 ± 8 | 74 ± 8 | 77 ± 6 | 77 ± 9 | 77 ± 7 | 79 ± 7 |
| HR (bpm) | 60 ± 9 | 59 ± 10 | 57 ± 12 | 61 ± 9 | 61 ± 7 | 59 ± 10 |
| CHS scores | 2.4 ± 1.8 | 3.4 ± 2.4 | 2.9 ± 1.9 | 2.6 ± 1.6 | 1.4 ± 0.6 | 1.6 ± 1.0 |
AD: Alzheimer’s disease; APOE: apolipoprotein E; DBP: diastolic blood pressure; HR: heart rate; MCI: mild cognitive impairment; SBP: systolic blood pressure; CHS: cardiovascular Health Study.
*Nineteen subjects not genotyped (seven AD, nine MCI, three middle-age APOE4-, FH-); carrier refers to presence of at least one APOE E4 allele.