. Author manuscript; available in PMC: 2021 Aug 17.

Published in final edited form as: Rev Soc Bras Med Trop. 2017 Jul-Aug;50(4):516–523. doi: 10.1590/0037-8682-0015-2017

TABLE 2.

Association of CASP1 polymorphisms between subjects with Class I and Class II/III/IV cardiomyopathy according to infection status, adjusted for age and sex.

SNP	Model	Genotype	Cardiac Classification (ABCD) and Odds Ratios
SNP	Model	Genotype	*Tc+*

			I	II/III/IV	I vs. II/III/IV
			N (%)	N (%)	OR (95% CI)

RS501192	Dominant	GG	31 (41.9)	34 (45.3)	0.89 (0.45–1.76)
		GA/AA	43 (58.1)	41 (54.7)
	Recessive	GG/GA	67 (90.5)	61 (81.3)	2.18 (0.80–5.92)^*
		AA	7 (9.5)	14(18.7)
RS570685	Additive		74 (49.7)	75 (49.7)	1.20 (0.75–1.94)
	Dominant	AA	24 (32.4)	26 (34.7)	0.90 (0.44–1.86)
		AC/CC	50 (67.6)	49 (65.3)
	Recessive	AA/AC	61 (82.4)	55 (73.3)	1.57 (0.70–3.53)
		CC	13 (17.6)	20 (26.7)
	Additive			75 (50.3)	1.11 (0.70–1.75)

			*Tc−*

SNP	Model	Genotype	I	II/III/IV	I vs. II/III/IV
			N (%)	N (%)	OR (95% CI)

RS501192	Dominant	GG	24 (45.3)	12 (35.3)	1.72 (0.67–4.41)
		GA/AA	29 (54.7)	22 (68.8)
	Recessive	GG/GA	46 (86.8)	25 (73.5)	2.57 (0.79–8.41)^**
		AA	7(13.2)	9 (26.5)
	Additive		53 (60.9)	34 (39.1)	1.51 (0.81–2.82)
RS570685	Dominant	AA	15 (28.3)	7 (20.6)	1.23 (0.42–3.58)
		AC/CC	38 (71.7)	27 (79.4)
	Recessive	AA/AC	43 (81.1)	22 (64.7)	2.57 (0.90–7.37)^***
		CC	10 (18.9)	12 (35.3)
	Additive		53 (60.9)	34 (39.1)	1.56 (0.81–3.01)

CASP1: caspase 1; ABCD: Cardiac classification; SNP: single nucleotide polymorphism; OR: odds ratios.

p = 0.117.

^**

p = 0.115.

^***

p = 0.075.