TABLE 3.

Association of CASP1 polymorphisms between asymptomatic (I) and cardiomyopathy patients (II/III/IV) accordingvto infection status, adjusted for age and sex.

			Cardiac Classification (I/II/III/IV) and Odds Ratios
SNP	Model	Genotype	I	I+	I− vs. I+
			N (%)	N (%)	OR (95% CI)
RS501192	Dominant	GG	24 (45.3)	31 (41.9)	1.12 (0.54–2.31)
		GG/AA	29 (54.7)	43 (58.1)
	Recessive	GG/GA	46 (86.8)	67 (90.5)	0.71 (0.23–2.22)
		AA	7(13.2)	7(9.5)
	Additive		53 (41.7)	74 (58.3)	0.99 (0.58–1.69)
RS570685	Dominant	AA	15 (28.3)	24 (32.4)	0.76 (0.35–1.68)
		AC/CC	38 (71.7)	50 (67.6)
	Recessive	AA/AC	43 (81.1)	61 (82.4)	0.90 (0.35–2.27)
		CC	10(18.9)	13 (17.1)
	Additive		53 (41.7)	74 (58.3)	0.86 (0.51–1.45)
SNP	Model	Genotype	II/III/IV−	II/III/IV+	II/III/IV− vs. II/III/IV+
			N (%)	N (%)	OR (95% CI)
RS501192	Dominant	GG	12 (35.3)	34 (45.3)	0.64 (0.27–1.51)
		GA/AA	22 (64.7)	41 (54.7)
	Recessive	GG/GA	25 (73.5)	61 (81.3)	0.64 (0.25–1.69)
		AA	9 (26.5)	14 (18.7)
	Additive		34 (31.2)	75 (68.8)	0.74[0.43 –1.25]
RS570685	Dominant	AA	7 (20.6)	26 (34.7)	0.46[0.17–1.24]
		AC/CC	27 (79.4)	49 (65.3)
	Recessive	AA/AC	22 (64.7)	55 (73.3)	0.67[0.28–1.61]
		CC	12 (35.3)	20 (26.7)
	Additive		34 31.2	75 (68.8)	0.67[0.39–1.16]
SNP	Model	Genotype	All Tc−	All Tc+	All Tc− vs. All Tc+
			N (%)	N (%)	OR (95% CI)
RS501192	Dominant	GG	36 (41.4)	65 (43.6)	0.87 (0.51–1.51)
		GA/AA	51 (58.6)	84 (56.4)
	Recessive	GG/GA	71 (81.6)	128 (85.9)	0.71 (0.35–1.47)
		AA	16(18.4)	21 (14.1)
	Additive		87 (36.9)	149 (63.1)	0.86 (0.59–1.25)
RS570685	Dominant	AA	22 (25.3)	50 (33.6)	0.62 (0.34–1.13)
		AC/CC	65 (74.7)	99 (66.4)
	Recessive	AA/AC	65 (74.7)	116 (77.9)	0.80 (0.43–1.51)
		CC	22 (25.3)	33 (22.1)
	Additive		87 (36.9)	149 (63.1)	0.77 (0.53–1.12)

CASP1: caspase 1; SNP: single nucleotide polymorphism; OR: odds ratios; Tc+: Trypanosoma cruzi positive; Tc−: Trypanosoma cruzi negative.