Table 3.
Disease-Specific Survival According to Risk Stratification
| Risk Group | Median Time, Months (95% CI) | 2-Year Rate, % (95% CI) | 5-Year Rate, % (95% CI) | 10-Year Rate, % (95% CI) | Hazard Ratio (95% CI) | P-value |
|---|---|---|---|---|---|---|
| Training/validation cohort (n=1899) | ||||||
| Low-risk (n=760) | Undefined | 95.2 (93.7–96.8) | 85.5 (82.7–88.5) | 75.6 (71.1–80.3) | 1 | |
| Intermediate-risk (n=948) | 93.0 (83.0–114.0) | 84.6 (82.3–87.0) | 63.0 (59.6–66.7) | 41.8 (36.7–47.6) | 3.039 (2.536–3.641) | <0.001* |
| High-risk (n=191) | 23.0 (20.0–28.0) | 48.2 (41.5–55.9) | 10.9 (6.6–18.2) | 5.7 (2.4–13.6) | 3.876 (2.907–5.169) | <0.001† |
| Test cohort (n=879) | ||||||
| Low-risk (n=634) | Undefined | 95.5 (93.9–97.2) | 81.2 (77.9–84.7) | 69.0 (63.8–74.6) | 1 | |
| Intermediate-risk (n=194) | 68.0 (51.8–80.6) | 78.6 (73.0–84.7) | 52.6 (45.2–61.3) | 37.9 (29.3–49.2) | 3.237 (2.289–4.578) | <0.001* |
| High-risk (n=51) | 26.0 (22.0–39.0) | 56.3 (44.1–71.8) | 18.9 (9.4–38.2) | 4.7 (0.8–29.7) | 2.607 (1.601–4.243) | <0.001† |
Note: *P value versus low-risk; †P value versus intermediate-risk.
Abbreviation: CI, confidence interval.