Table 1.
GRADE evidence profile table for PICO 1.
|
Certainty assessment |
No. of patients |
Effect |
Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Surgical decompression | Medical management | Relative (95% CI) | Absolute (95% CI) | ||
| PICO 1: Death, Age 18-60 years, ≤ 48 hr | ||||||||||||
| 7 | randomised trials | seriousa | not serious | not serious | not serious | large effect | 25/108 (23.1%) | 73/109 (67.0%) | RR 0.36(0.25 to 0.53) | 429 fewer per 1,000(from 502 fewer to 315 fewer) | ⨁⨁⨁⨁HIGH | critical |
| PICO 1: Death or moderately severe disability (mRS 4-6), Age 18-60 years, ≤ 48 hr | ||||||||||||
| 7 | randomised trials | seriousa, b | not serious | not serious | not serious | large effect | 64/108 (59.3%) | 85/109 (78.0%) | RR 0.79(0.63 to 0.99) | 164 fewer per 1,000(from 289 fewer to 8 fewer) | ⨁⨁⨁◯MODERATE | critical |
CI: confidence interval; RR, risk ratio.
aFour trials terminated prematurely.
bLack of blinding.