Table 2.
GRADE evidence profile table for PICO 2.
|
Certainty assessment |
No. of patients |
Effect |
Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Surgical decompression | Medical management | Relative (95% CI) | Absolute (95% CI) | ||
| PICO 2: Death, Age 18-60 years, > 48 hr | ||||||||||||
| 2 | randomised trials | seriousa | not serious | not serious | seriousb | small numbers of trials and patients | 5/17 (29.4%) | 6/17 (35.3%) | RR 0.82(0.30 to 2.28) | 64 fewer per 1,000(from 247 fewer to 452 more) | ⨁⨁◯◯LOW | critical |
| PICO 2: Death or moderately severe disability (mRS 4-6), Age 18-60 years, > 48 hr | ||||||||||||
| 2 | randomised trials | seriousa,b | not serious | not serious | seriousb | small numbers of trials and patients | 12/17 (70.6%) | 11/17 (64.7%) | RR 1.07(0.67 to 1.72) | 45 more per 1,000(from 214 fewer to 466 more) | ⨁⨁◯◯LOW | critical |
CI: confidence interval; RR: risk ratio.
aTrials terminated prematurely.
bLack of blinding.