Table 3.
GRADE evidence profile table for PICO 3.
|
Certainty assessment |
No. of patients |
Effect |
Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Surgical decompression | Medical management | Relative (95% CI) | Absolute (95% CI) | ||
| PICO 3: Death, Age > 60 years | ||||||||||||
| 4 | randomised trials | seriousa | not serious | not serious | not serious | large effect | 33/110 (30.0%) | 89/123 (72.4%) | RR 0.40(0.24 to 0.67) | 434 fewer per 1,000(from 550 fewer to 239 fewer) | ⨁⨁⨁⨁HIGH | critical |
| PICO 3: Death or moderately severe disability (mRS 4-6), Age > 60 | ||||||||||||
| 4 | randomised trials | seriousa,b | serious | not serious | serious | none | 72/110 (65.5%) | 109/123 (88.6%) | RR 0.72(0.41 to 1.28) | 248 fewer per 1,000(from 523 fewer to 248 more) | ⨁⨁◯◯LOW | critical |
CI: confidence interval; RR: risk ratio.
aTwo trials terminated prematurely.
bLack of blinding.