Table 5.
GRADE evidence profile table for PICO 13.
|
Certainty assessment |
No. of patients |
Effect |
Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Glyburide | placebo | Relative (95% CI) | Absolute (95% CI) | ||
| PICO 13: Mortality, 3 months | ||||||||||||
| 1 | randomised trials | seriousa | not serious | not serious | not serious | single study | 7/41 (17.1%) | 13/36 (36.1%) | RR 0.47(0.21 to 1.05) | 191 fewer per 1,000(from 285 fewer to 18 more) | ⨁⨁◯◯LOW | critical |
| PICO 13: Poor outcome (mRS 4-6) | ||||||||||||
| 1 | randomised trials | seriousa | not serious | not serious | serious | single study | 27/41 (65.9%) | 27/36 (75.0%) | RR 0.88(0.66 to 1.17) | 90 fewer per 1,000(from 255 fewer to 127 more) | ⨁◯◯◯VERY LOW | critical |
CI: confidence interval; RR: risk ratio.