Table 4.
Evidence profile table for safety and efficacy of intensive systolic blood pressure lowering (target 130–140 mmHg within 1 hour) compared to guideline-recommended systolic blood pressure levels (<180 mm Hg) over 72 hours following symptom onset in acute ischaemic stroke patients receiving intravenous thrombolysis.
| Certainty assessment |
№ of patients |
Effect |
Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Experimental arm | Control arm | Relative (95% CI) |
Absolute (95% CI) |
||
| 3 months mortality | ||||||||||||
| 1 | Randomised trial | Unclear | N/A | Not serious | Very serious | N/A | 102/1081 (9.4%) | 88/1115 (7.9%) | OR 1.22 (0.90 to 1.64) |
16 more per 1,000 (from 7 fewer to 44 more) |
⨁◯◯◯ Very low |
Critical |
| 3 months good functional outcome (mRS scores 0–2) | ||||||||||||
| 1 | Randomised trial | Unclear | N/A | Not serious | Very serious | N/A | 712/1072 (66.4%) | 734/1108 (66.4%) | OR 1.00 (0.83 to 1.20) |
0 fewer per 1,000 (from 38 fewer to 42 more) |
⨁◯◯◯ Very low |
Critical |
| 3 months improved mRS scores (shift analysis) | ||||||||||||
| 1 | Randomised trial | Unclear | N/A | Not serious | Very serious | N/A | – | – | common OR 1.01 (0.87 to 1.17) |
- | ⨁◯◯◯ Very low |
Critical |
CI: confidence interval; OR: odds ratio.