Table 5.
Randomized controlled clinical trials evaluating different blood pressures targets following mechanical thrombectomy in acute ischaemic stroke patients with large vessel occlusion receiving endovascular therapies.
| Study | Location | N patients | Experimental targets | Standard target | Randomization | Period of intervention | Termination date |
|---|---|---|---|---|---|---|---|
| BEST-II (109) | USA (Cincinnati & Nashville) | 120 | 140–160 mmHga 110–140 mmHgb |
160–180 mmHg | N/A | 24 hours | March 2023 |
| DETECT(111) | Canada (Hamilton) | 30 | <140 mmHg | <180 mmHg | 1 hour | 48 hours | June 2022 |
| ENCHANTED2(110) | International | 2236 | <120 mmHg | 140–180 mmHg | 3 hours | 72 hours | February, 2023 |
| OPTIMAL BP (112) | Korea (multicenter) |
644 | <140 mmHg | <180 mmHg | 0.5-1 hour | 24 hours | December 2023 |
| BP-TARGET (113,114) | France (multicenter) | 320 | <130 mmHg | <185 mmHg | 1 hour | 24–36 hours | Completed No differences in clinical or imaging endpoints between the two randomization arms |
aFirst active comparator arm of BEST-II.
bSecond active comparator arm of BEST-II.