Table 8.
Evidence profile table for continuing versus temporarily stopping previous blood-pressure lowering therapy in patients with acute ischemic stroke.
| Certainty assessment |
№ of patients |
Effect |
Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Continuing | Stopping previous antihypertensive therapy | Relative (95% CI) |
Absolute (95% CI) |
||
| 3–6 months mortality | ||||||||||||
| 2 | Randomised trials* | Not serious | Not serious | Not serious | Seriousa | Publication bias strongly suspectedb | 170/1145 (14.8%) | 135/1100 (12.3%) | OR 1.25 (0.98 to 1.60) |
26 More per 1,000 (From 2 fewer to 60 more) |
⨁⨁◯◯ Low |
Critical |
| 3–6 months good functional outcome (mRS scores 0–2) | ||||||||||||
| 2 | Randomised trials* | Not serious | Not serious | Not serious | Seriousa | publication bias strongly suspectedb | 434/1145 (37.9%) | 428/1100 (38.9%) | OR 0.95 (0.80 to 1.13) |
12 Fewer per 1,000 (From 52 fewer to 29 more) |
⨁⨁◯◯ Low |
Critical |
CI: confidence interval; OR: odds ratio.
aWide confidence intervals.
bTwo studies reported this outcome