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. Author manuscript; available in PMC: 2023 Oct 3.
Published in final edited form as: J Am Chem Soc. 2021 Aug 10;143(33):13205–13211. doi: 10.1021/jacs.1c05435

Figure 2. Transformation of prefusion S to mature S2 at a hemifusion stalk.

Figure 2.

Maturation of S2 frees FP for membrane insertion and fusion. The structures of postfusion S2, ACE2, an ACE2-S complex, and the TM domain are from refs 11-14, respectively.