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. 2021 Aug 9;1(1):15–37. doi: 10.1021/acsnanoscienceau.1c00009

Figure 23.

Figure 23

Schematic representation of the hepatitis C virus/luciferase reporter construct. The HCV polyprotein open reading frame was replaced by the FLuc gene. MicroRNA-122 binding sites 1 and 2 are depicted by gray rectangles, with Argonaute/microRNA (gray ovals) bound indicating its function in inhibiting Xrn-1 and stimulating translation of luciferase. Xrn-1: exoribonuclease. UTR: untranslated region. IRES: internal ribosome entry site. Adapted with permission from ref (109). Copyright 2018 Jost et al.