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. 2021 Aug 9;1(1):15–37. doi: 10.1021/acsnanoscienceau.1c00009

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© 2021 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Schematic representation of the genome of a HiBiT-tagged HCV. Arrows indicate locations for insertion of HiBiT in the HCV genome to construct 10 different candidate tagged viruses. The clone with placement of the tag at NS2 (red arrow) provided the highest viral titer and stronger luciferase activity. HCV JFH1: hepatitis C virus (HCV) genotype 2a isolate. E1 and E2: two subunits of the envelope glycoprotein found in HCV. NS2, NS3, NS4, and NS5: nonstructural proteins in HCV. p7: membrane-associated ion channel protein. Linker (4GS): glycine–serine-rich linker. Adapted with permission from ref (35). Copyright 2018 American Society for Microbiology.