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. 2021 Jun 29;12(8):1245–1252. doi: 10.1021/acsmedchemlett.1c00032

Figure 5.

Figure 5

Hershberger assay: Dosing effect of compounds 16 (30 mg/kg), 19 (5 mg/kg), (S)-26 (30 mg/kg), and (R)-28 (30 mg/kg) compared with control group 1 (enzalutamide, 30 mg/kg) and (R)-29 (5 mg/kg) and (S)-27 (5 mg/kg) compared with control group flutamide (3 mg/kg) on ASOs. The ASO development of seminal vesicles and coagulating glands (SVCG) and the ventral prostate (VP) is shown. The compound-dependent suppression of ASOs is significant for each compound tested (p ≤ 0.0001, t-test/Mann–Whitney). Data are the mean ± SD (n = 6).