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. 2021 Jun 29;12(8):1245–1252. doi: 10.1021/acsmedchemlett.1c00032

Scheme 2. Synthesis of Spirocyclic Thiohydantoin or Hydantoin Analogues 11–15.

Scheme 2

Reagents and conditions: (a) Boc2O, TEA, DCM, rt; (b) MeI, NaH, DMF, rt; (c) MeNHOMe·HCl, W(CO)6 (cat.), Pd(OAc)2 (cat.), Xantphos (cat.), DMAP, K3PO4, 1,4-dioxane, microwave, 120 °C; (d) TFA, DCM, rt; (e) TEA, THF, DMF, 80 °C.