Scheme 4. Synthesis of Spirocyclic Thiohydantoin Analogues 23–25.
Reagents and conditions: (a) Zn(CN)2, Pd2dba3, PPh3, DMA, 120 °C; (b) aqueous conc. HCl, 135 °C; (c) TEA, THF/DMF, 80 °C; (d) NH4Cl, HBTU, DIPEA, DMAP (cat.), DMF, rt.
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