TABLE 3.

Comparison of clinical characteristics and outcomes

Parameter	Values for:		P value
	Control group (n = 202)	Melatonin group (n = 101)
No. (%) of patients with acute kidney injury	33 (16.3)	8 (7.9)	0.043
No. (%) of patients with an sCr >0.3 mg/dl from baseline	32 (15.8)	8 (7.9)	0.055
No. (%) of patients with an sCr increase >50% from baseline	18 (8.9)	5 (5.0)	0.220
Mean length of stay (days) ± SD	8.4 ± 7.8	12.1 ± 17.1	0.044
Mean AUC (mg · h/liter) ± SD	487.4 ± 215.9	479.2 ± 256.7	0.770
Mean initial trough (μg/ml) ± SD	16.2 ± 6.6	16.7 ± 6.6	0.632
Median change in CLCR from baseline (ml/min) [IQR]a	3.5 [17.1]	11.0 [27.2]	0.047
Mean change in sCr (mg/dl) from baseline ± SD	0.1 ± 0.5	−0.1 ± 0.4	0.007

^aIQR, interquartile range.