TABLE 4.
Multivariable logistic regression for factors associated with AKIa
| Parameter | Univariate |
Multivariableb
|
||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Melatonin | 0.44 (0.20–0.99) | 0.048 | 0.37 (0.14–0.96) | 0.041 |
| Age ≥ 65 yrs | 1.75 (0.90–3.41) | 0.100 | ||
| AUC > 600 mg · h/liter | 11.6 (5.61–24.28) | <0.001 | 11.6 (5.15–26.2) | <0.001 |
| CCI > 3 | 2.52 (1.26–5.06) | 0.030 | ||
| CLCR ≥ 60 ml/min | 0.45 (0.21–0.95) | 0.036 | 0.36 (0.15– 0.91) | 0.030 |
| Use of loop diuretics | 3.37 (1.70–6.7) | 0.001 | ||
| ICU admission | 5.99 (2.99–11.98) | <0.001 | 4.17 (1.90–9.18) | <0.001 |
| Piperacillin-tazobactam | 3.90 (1.83–8.29) | <0.001 | ||
a
Abbreviations: AUC, area under the curve; CCI, Charlson-Deyo comorbidity index; CLCR, creatinine clearance; ICU, intensive care unit.
b
Only covariates with a P of ≤0.1 were considered for further testing in the multivariable model.