FIG 3.

Changes in general conditions of the body after PJI rat model establishment, one-stage revision, and corresponding drug treatment in each group. (A) Body weight change curves (n = 12). (B) Body temperature change curves (n = 12). (C) Changes in serum α₁-AGP levels during the whole experiment (for the tests on days 0, 7, and 14, n = 6; for the test on day 21, n = 12). (D) Local right knee skin temperature change curves (n = 12). (E) Typical infrared thermal imaging after PJI rat model establishment, revision, and vancomycin treatment of rats in each group (n = 6). Control (no antibiotics), IP injection of vancomycin (88 mg/kg, q12h), IA injection of vancomycin (44 mg/kg, qd), and IP plus IA injection of vancomycin (combined IP treatment at 88 mg/kg, q12h, and IA treatment at 44 mg/kg, qd) were assessed. The time indicated by the blue triangles is the knee arthroplasty operation and IA inoculation of MRSA in rats, while the time indicated by the red circles is the operation for debridement and implantation of a new elongated revision prosthesis (one-stage revision) in rats. *, P < 0.05; **, P < 0.01. Significance was evaluated using a two-way ANOVA for the comparison of general animal status (weight, body temperature, and local skin temperature of the knee) in different treatment groups.