TABLE 1.

Serum vancomycin levels in each treatment group

Groupa	Vancomycin level (μg/ml)b
	Preinjection	0.5 h	2 h	4 h
Control	0	0	0	0
IA	c	5.64 ± 0.82	3.55 ± 0.26	c
IP	c	9.39 ± 1.35	4.04 ± 0.35	c
IP plus IA	c	14.31 ± 1.35	9.75 ± 1.07	1.59 ± 0.40

^aControl (no antibiotics), IP injection of vancomycin (88 mg/kg, q12h), IA injection of vancomycin (44 mg/kg, qd), and IP and IA injection of vancomycin (combined IP treatment at 88 mg/kg, q12h, and IA treatment at 44 mg/kg, qd) were assessed (n = 6).

^bSerum vancomycin levels were detected before the last injection and 0.5, 2, and 4 h after vancomycin injection in each treatment group on day 21.

^cBelow the limit of detection (1 μg/ml).