. 2021 Aug 17;65(9):e00699-21. doi: 10.1128/AAC.00699-21

TABLE 1.

Antifungal activity and selectivity of BPQ against Sporothrix brasiliensis compared to ITC^a

Compound	MIC_range	MIC_median	MFC_range	LLC-MK₂ cell CC₅₀	Selectivity index
BPQ	0.005–0.16	0.02*	2.61–>2.61	8.16	408
ITC	0.005–0.16	0.08	2.61–>2.61	>70.5	>881.25

Results are expressed in microgram per milliliter, n = 20. MIC, MIC that inhibits ≥50% of fungal growth. MFC, minimum fungicidal concentration that kills ≥99.9% of fungal cells. CC₅₀, concentration that elicited 50% cytotoxicity. Selectivity index, ratio between CC₅₀ and MIC_median. *, P = 0.0034 compared with MIC values for ITC (by Wilcoxon test).