FIG 1.

In vitro efficacy of ELQ analogs against B. duncani in human RBCs. (a) Chemical structure of ELQs used in this study. (b) Twenty-eight ELQ derivatives were evaluated in vitro against B. duncani at 1 μM and 100 nM. WR99210, a potent antiparasitic drug (25, 26), was used as a positive control and used to determine 100% growth inhibition. (c and d) Structure and potency of ELQ drugs and prodrugs against B. duncani and IC₅₀ determination using ELQ-447 and ELQ-502 (c) and ELQ-316 and ELQ-334 (d).