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. 2021 Aug 17;65(9):e00602-21. doi: 10.1128/AAC.00602-21

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Copyright © 2021 Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 6 — Effect of CES1 inhibitor BNPP and CatA inhibitor telaprevir on formation of active metabolite GS-443902 in RDV-treated NHBE (A) and antiviral activity against SARS-CoV-2 in A549-hACE2 cells (B). (A) Cells from three different donors were incubated with 1 μM RDV and DMSO (gray dotted bar), BNPP (filled bar), and telaprevir (open bar) and harvested at 24 h post-compound addition. Triphosphate (TP) levels are shown as average ± standard deviation of the percentage of the DMSO control across the three donors. One-way ANOVA was used for statistical analysis. (B) Effect of increasing telaprevir concentrations on potency of RDV against SARS-CoV-2 replication in A549-hACE2 cells. The RDV titration curve in the presence of either DMSO alone (black circles) or 0.5 (green boxes), 2.5 (blue diamonds), or 10 μM telaprevir (red triangles) from one of three experiments is displayed. The levels are shown as average ± standard deviation from three replicates. Two-way ANOVA was used for statistical analysis.