TABLE 3.

Hydrolysis of RDV by key metabolic enzymes^a

Compound	Activity for amidate ester cleavage (nmol/min/mg) (t1/2 [min]) for enzyme:
	CES1b	CES1c	CES2	CatA
RDV	4.8 ± 0.4 × 10−2 (9.7 ± 0.8)	6.1 ± 0.4 × 10−2 (7.7 ± 0.5)	2.8 ± 2.6 × 10−4 (> 1000)	74 ± 32 (43 ± 25)
Control
Oseltamivir	2.3 ± 0.1 × 10−2 (20 ± 1)	1.5 ± 0.2 × 10−2 (31 ± 4)
Procaine			4.4 ± 0.8 × 10−3 (110 ± 20)
TAF (GS-7340)				254 ± 154 (13 ± 6)

^aValues represent the average ± standard deviation from three independent measurements. t_1/2, half-life.