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Hydrolysis of RDV MetX and control compounds by HINT1 or acidic hydrolysisa
| Compound | HINT1 hydrolysis (nmol/min/mg) (t1/2 [min]) | Lysosomal hydrolysis at pH 4.5 (nmol/min) (t1/2 [min]) |
|---|---|---|
| RDV MetX | 32 ± 12 (5.5 ± 2.3) | 0 ± 0 (>104) |
| Control | ||
| GS-6620 MetX | 5.3 ± 2.4 (38 ± 30) | |
| TAF MetX | 1.2 ± 0.6 × 10−3 (16 ± 7) |
Values represent the average ± standard deviation of three independent measurements.
