Figure 1.

Genomic variants and neuroimaging alterations associated with ASD and schizophrenia. Top: Common and rare genetic variants (in green and blue, respectively) associated with ASD (left) or schizophrenia (SZ, right).^25–30Top middle: Genomic variants associated with both conditions and genetic correlation between ASD and schizophrenia.²⁶Bottom: Structural and resting-state functional MRI (in blue and green, respectively) intermediate brain phenotypes associated with ASD (right) or schizophrenia (left). Results were reported based on meta-analyses or from the largest study to date.^31–42Bottom middle: Shared anatomical and functional alterations associated with ASD and schizophrenia.^43–45 BP = breakpoint; CT = cortical thickness; d = dorsal; Del = deletion; Dup = duplication; FC = functional connectivity; FPN = frontoparietal network; SA = surface area; SN = salience network; v = ventral; vol = volume.