Table 1.

Histopathological and MRI findings in DGM and related grey matter regions in multiple sclerosis

	Histopathological findings						MRI findings
	Lesions	Normal-appearing tissue
DGM Structure	Focal lesions present16–18	Diffuse inflammatory infiltrate16,17	Activated microglia16–18	Iron deposition16,*	Neuronal loss16,17	Markers of oxidative stress16	Early volume loss19–21	DGM lesions MRI-visible22–24	Iron accumulation25–27
Thalamus16–20,22	+++	+	+	+	+	+	+++	+++	+
Caudate16,17,20,23	+++	+	+	+	+	+	++	+	+
Putamen16,17,19,20,23	++	+	+	+	+	+	+++	+	+
Globus pallidus16,17	++	+	+	+	+	+	NA	NA	+
Substantia nigra17	+	+	NA	NA	NA	NA	NA	NA	NA
Amygdala17	+	+	NA	NA	NA	NA	NA	NA	NA
Hypothalamus17,28	+++	+	+	NA	+	NA	NA	NA	NA
Hippocampus29–32	+++	NA	+	NA	+	NA	+	+++	NA

NA = not available.

^*Did not reach statistical significance.