Figure 3.

Variation in cognitive‘ decline explained by the pathological indices (dark grey) and the residual, unexplained variation in cognitive decline (light grey) derived from fully adjusted models. Alzheimer’s disease (AD) = neurodegenerative pathologies related to Alzheimer’s disease, i.e. global Alzheimer’s disease pathology, amyloid-β and PHFtau tangles; CVD = cerebrovascular indices, i.e. gross infarcts, microscopic infarcts, atherosclerosis, arteriolosclerosis, cerebral amyloid-β angiopathy; non-Alzheimer’s disease (non-AD) = neurodegenerative pathologies, i.e. Lewy bodies, hippocampal sclerosis and LATE-NC.