Table 4.

Variances explained‘ by each of the pathological indices and combinations thereof

Predictor	Global cognition decline
	Total variance	Reduction	% Total variance explained
Reference model	0.0094	–	–
Separate models
Global Alzheimer’s disease pathology	0.0069	0.0025	27%
Amyloid-β	0.0082	0.0012	13%
PHFtau tangles	0.0061	0.0033	35%
Neocortical Lewy bodies	0.0090	0.0004	4%
LATE-NC (4 stages)	0.0088	0.0006	7%
Hippocampal sclerosis	0.0091	0.0003	3%
Gross infarcts, chronic	0.0093	0.0001	1%
Microscopic infarcts, chronic	0.0094	0.0000	0%
Atherosclerosis	0.0092	0.0002	3%
Arteriolosclerosis	0.0093	0.0001	2%
Cerebral amyloid angiopathy	0.0090	0.0004	5%
Multivariate models
Six pathologiesa	0.0057	0.0037	40%
All 11 pathologies	0.0054	0.0040	43%

^aIncludes global‘ Alzheimer’s disease pathology, amyloid-β, PHFtau tangles, neocortical Lewy bodies, gross infarcts, and microscopic infarcts.