Table 3.
Growth calculation results and subgroup analysis
| Interval between 1st and 2nd CT (days) | Change in tumour length (mm) | Specific length growth rate (%) | Change in tumour volume (cm3) | Volume increase from baseline (%) | Tumour doubling time (days) | Absolute growth per 62 days (mm) | Volume growth per 62 days (cm3) | |
|---|---|---|---|---|---|---|---|---|
| All tumours (n = 43) | 150 (72–472) | 9·5 (2·0–22·3) | 23·5 (3·4–53·5) | 18·3 (7·9–48·0) | 102·2 (43·1–292·4) | 211 (112–404) | 2·23 (0·86–4·89) | 6·85 (1·68–13·58) |
| Anatomical location | ||||||||
| Right colon (n = 21) | 335 (115–650) | 16·0 (0·5–31·0) | 41·0 (0·4–68·2) | 24·7 (7·6–72·1) | 175·2 (69·0–462·8) | 211 (100–598) | 1·75 (0·28–4·93) | 5·21 (1·53–12·85) |
| Left colon (n = 16) | 142 (3–326) | 7·5 (0–15·8) | 15·7 (0·04–38·2) | 14·1 (0·03–35·9) | 55·8 (0·2–204·1) | 227 (179–409) | 2·87 (2·62–5·03) | 7·01 (1·74–11·71) |
| Rectum (n = 6) | 280 (59–983) | 15·0 (1·3–26·0) | 31·6 (2·5–66·2) | 31·6 (2·5–66·1) | 26·9 (7·7–57·9) | 142 (99–343) | 2·34 (0·49–5·63) | 8·15 (2·24–13·63) |
| P * | 0·276 | 0·510 | 0·418 | 0·498 | 0·059 | 0·609 | 0·698 | 0·867 |
| Mucinous type | ||||||||
| Yes (n = 10) | 227 (96–379) | 16·5 (1·8–32·0) | 36·1 (1·1–57·6) | 63·8 (22·6–152·6) | 214·1 (67·2–405·4) | 168 (105–265) | 2·91 (0·99–6·87) | 13·86 (8·02–29·46) |
| No (n = 33) | 167 (96–577) | 9·0 (2·0–20·0) | 20·0 (3·7–51·4) | 15·5 (8·8–32·8) | 81·6 (38·2–286·3) | 235 (117–434) | 2·02 (0·85–4·72) | 6·20 (1·53–8·70) |
| P * | 0·367 | 0·369 | 0·274 | 0·008 | 0·162 | 0·181 | 0·273 | 0·003 |
| T category change | ||||||||
| Progression (n = 31) | 182 (114–518) | 10·0 (2·0–22·0) | 23·3 (3·4–51·1) | 19·5 (9·7–60·0) | 119·0 (46·9–327·1) | 204 (123–419) | 1·75 (0·84–4·89) | 6·85 (1·68–13·58) |
| Stable (n = 12) | 121 (90–362) | 11·0 (2·3–32·6) | 23·2 (3·0–63·4) | 21·0 (7·1–45·8) | 63·4 (18·5–286·2) | 237 (110–401) | 2·57 (1·93–5·23) | 7·13 (1·43–21·97) |
| P * | 0·118 | 0·391 | 0·446 | 0·412 | 0·120 | 0·443 | 0·219 | 0·447 |
| T category progression | ||||||||
| T2 → T3/T4 (n = 12) | 485 (307–957) | 15·0 (0·5–28·3) | 44·1 (1·2–68·0) | 30·1 (10·5–56·8) | 269·1 (133·0–821·4) | 203 (151–581) | 0·91 (0·23–2·62) | 2·92 (1·51–9·76) |
| T3 → T4 (n = 19) | 136 (105–337) | 9·5 (2·8–19·0) | 17·2 (5·1–42·0) | 46·2 (9·3–53·8) | 71·5 (32·5–226·1) | 199 (105–335) | 2·57 (1·04–8·69) | 7·78 (4·81–14·38) |
| P * | P= 0·002 | 0·251 | 0·143 | 0·208 | 0·002 | 0·201 | 0·035 | 0·059 |
| N category change | ||||||||
| Progression (n = 25) | 204 (100–505) | 10·0 (2·5–26·5) | 23·3 (3·1–54·8) | 27·4 (10·3–64·5) | 104·7 (36·8–487·4) | 211 (117–363) | 2·81 (0·90–5·17) | 8·95 (2·04–14·56) |
| Stable (n = 18) | 152 (96–447) | 9·0 (1·3–18·0) | 21·1 (2·3–50·0) | 14·6 (7·9–27·4) | 80·7 (44·6–255·3) | 208 (112–629) | 1·56 (0·55–5·13) | 5·70 (1·41–8·07) |
| P * | 0·387 | 0·222 | 0·354 | 0·068 | 0·111 | 0·332 | 0·288 | 0·274 |
| M category change | ||||||||
| Progression (n = 11) | 155 (66–635) | 18·0 (3·0–32·0 | 41·9 (5·7–60·0) | 18·1 (8·5–57·0) | 84·5 (33·2–550·9) | 172 (112–374) | 3·12 (1·07–8·27) | 7·98 (5·21–15·71) |
| Stable M0 (n = 25) | 331 (124–512) | 12 (12·5 –23·8) | 30·0 (3·0–62·8) | 27·4 (11·2–67·9) | 202·8 (55·0–388·7) | 221 (155–401) | 2·23 (0·87–4·04) | 6·61 (1·99–13·89) |
| Stable M1 (n = 7) | 108 (91–150) | 3·0 (0–8·0) | 7·7 (2·6–20) | 9·1 (1·0–23·7) | 27·3 (3·3–93·9) | 213 (60–1091) | 1·24 (0·26–4·56) | 6·26 (0·41–10·56) |
| P * | 0·082 | 0·086 | 0·101 | 0·093 | 0·078 | 0·842 | 0·457 | 0·399 |
Values are median (i.q.r.).
*
Kruskal–Wallis ANOVA.