Table 3.

Treatment-by-Time and Time Effects for Cognitive Function.

		Baseline Mean ± SD	Week-6 Mean ± SD	Week-12 Mean ± SD	Treatment-by-Time p-Value	Treatment-by-Time β	Treatment-by-Time 95% CI	Time p-Value	Time β	Time 95% CI
Processing Speed	Topiramate	48.4 ± 6.1	47.3 ± 6.1	53.5 ± 3.6	0.844	−0.05	−0.52 to 0.44	0.002	0.56	0.22 to 0.89
	Placebo	45.9 ± 13.5	51.6 ± 10.6	54.8 ± 12.7
WorkingMemory $	Topiramate	8.9 ± 1.3	8.1 ± 1.5	8.9 ± 1.0	0.301	−0.05	−0.14 to 0.05	0.191	0.04	−0.02 to 0.11
	Placebo	9.7 ± 2.7	10.3 ± 2.4	10.5 ± 1.4
Mental Switching	Topiramate	48.7 ± 9.3	49.5 ± 7.7	53.9 ± 7.7	0.902	0.03	−0.54 to 0.61	0.037	0.42	0.03 to 0.82
	Placebo	48.7 ± 11.6	52.6 ± 11.6	55.3 ± 9.0
Cognitive Inhibition	Topiramate	44.4 ± 8.4	50.8 ± 8.1	47.6 ± 9.3	0.915	0.03	−0.58 to 0.64	0.127	0.32	−0.10 to 0.74
	Placebo	47.8 ± 11.0	47.7 ± 12.1	52.3 ± 12.2
Verbal Fluency	Topiramate	53.0 ± 8.9	43.9 ± 10.3	50.2 ± 6.9	0.028	−0.55	−1.05 to −0.65	0.044	0.35	0.01 to 0.69
	Placebo	49.3 ± 12.9	53.3 ± 10.9	54.8 ± 11.9
Auditory-Verbal Learning	Topiramate	37.9 ± 12.7	37.2 ± 10.6	38.3 ± 13.6	0.826	0.08	−0.62 to 0.78	0.953	0.01	−0.47 to 0.50
	Placebo	41.0 ± 10.9	42.4 ± 11.3	42.8 ± 12.7
Auditory-Verbal Recall	Topiramate	39.7 ± 12.6	38.8 ± 13.6	39.4 ± 11.2	0.965	0.02	−0.80 to 0.84	0.911	0.03	−0.53 to 0.60
	Placebo	37.2 ± 12.3	43.0 ± 12.1	38.8 ± 17.3

Abbreviations: SD, Standard Deviation; β, beta; CI, confidence interval; significant covariate predictor of

^$Wechsler Test of Adult Reading

^#milligrams taken; Mean scores for Processing Speed, Mental Switching, Cognitive Inhibition, Verbal Fluency, Auditory-Verbal Learning and Recall, and Decision Making are expressed in t-scores; Working Memory is expressed as a scaled score; Risk-Taking is the average number of adjusted pumps; Choice Impulsivity is the mean hyperbolic k parameter estimate; Motor Impulsivity is stop signal reaction time in milliseconds.