Table 1.

Clinical characteristics of patients with CMML

Diagnosis a	N	Age median (years)	Gender M/F	Karyotype normal/abnormal (N)	Sub-classification
					MD-CMML (N)	MP-CMML (N)
CMML-1	96	74	67/29	55/41	54	42
CMML-2	27	70	22/5	13/14	18	9
sAML	27	69	15/12	15/12	14	13
Total CMML	150		104/46	83/67	86	64
M4/M5b	64	59	34/30	41/16
JMMLc	92	19d	61/31	77/15
Sum	156

Abbreviations: CMML, chronic myelomonocytic leukemia; sAML, secondary acute myeloid leukemia; JMML, juvenile myelomonocytic leukemia; M, male; F, female; MD, myelodysplastic; MP, myeloproliferative; TDS, targeted deep sequencing; WES, whole-exome sequencing.

^aWHO 2008 CMML: 31 cases were analyzed by WES, 93 cases were analyzed by TDS and 26 cases were analyzed by Sanger sequencing.

^bTCGA cohort: 64 M4/M5 were analyzed by WES.

^cJMML: 13 out of 92 cases were sequenced by WES and all cases were analyzed by TDS.²

^dMedian age in months. For cytogenetic information see Supplementary Table 3.