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. 2021 Mar 16;3(1):42–67. doi: 10.1089/bioe.2019.0034

Table 5.

Caenorhabditis elegans Channelopathies

Protein (gene) UniProt number Channel type Mutant phenotype Reference
acr-2 P48182 Ligand-gated cation channel Increased length and girth, abnormal gonad morphology 71
acr-6 Q9N4M3 Ligand-gated cation channel Increased girth 71
acr-7 P45963 Ligand-gated cation channel Increased length 71
acr-9 Q18556 Ligand-gated cation channel Reduced girth 71
acr-10 Q21645 Ligand-gated cation channel Increased girth 71
acr-14 Q22224 Ligand-gated cation channel Increased girth 71
acr-15 O16926 Ligand-gated cation channel Reduced girth and length 71
acr-18 G5EG72 Ligand-gated cation channel Reduced girth and length 71
acr-19 B3WFZ2 Ligand-gated cation channel Decreased body length and increased girth 71
acr-21 A0A3P6MY71 Ligand-gated cation channel Increased girth 71
acr-23 G5EG88 Ligand-gated cation channel Increased girth 71
che-6 O61827 Cyclic nucleotide-gated channel Abnormal sensillum morphology 244
eat-4 P34644 Glu/Na+ symporter Abnormal pharynx morphology 245
eat-6 P90735 Na+/K+ ATPase Abnormal sarcomere morphology, decreased girth and body length, abnormal pharynx 245–247
egl-2 A0A0K3AVF4 Voltage-gated K+ channel Increased length and girth, abnormal chemosensory neurons 71,248
egl-19 Q8MQA1 Voltage-gated Ca2+ channel Variable body length, decreased girth, blocked anus, tail morphology defects, pigmentation defects 71,245,246,249–251
egl-23 C0Z3L1 K+ two-pore domain channel Decreased body length and increased girth 71,246
egl-36 G5EFC3 Voltage-gated K+ channel Increased body length and girth 71
exc-4 Q8WQA4 Voltage-gated Cl− channel Defects in excretory canal, pigmentation defects 252
exp-2 H2KZQ6 Voltage-gated K+ channel Abnormal pharyngeal muscles, pharyngeal disorganization 246,253,
flr-1 G5EGI5 Degenerin/epithelial Na+ channel Pigmentation defects, reduced body length, reduced girth 71,249
lev-1 Q27218 Ligand-gated cation channel Reduced girth and body length 71
lev-8 Q93329 Ligand-gated cation channel Increased body length and girth 71
lov-1 Q09624 Transient receptor potential channel Increased girth 71,254
mec-10 P34886 Epithelial Na+ channel Variable body length and increased girth 71
mod-1 Q9GQ00 Ligand-gated Cl− channel Increased body length and girth 71
unc-77 V6CKM5 Na+ leak channel Decreased body length and girth 71
ocr-3 Q22374 Transient receptor potential channel Increased girth 71
ocr-4 Q9N3Y9 Transient receptor potential channel Decreased body length and increased girth 71
osm-9 G5EBV8 Transient receptor potential channel Reduced girth and decreased body length, abnormal uterine seam cells 71,255
sup-9 O17185 K+ two-pore domain channel Increased girth and length 71
tax-4 Q03611 Cyclic nucleotide-gated channel Failure of left/right asymmetric neuronal fate specification, abnormal sensory neurons 256,257
trp-1 P34586 Transient receptor potential channel Increased girth 71
trp-2 Q8I6Y9 Transient receptor potential channel Decreased body length and increased girth 71
trp-4 Q9GRV5 Transient receptor potential channel Increased girth 71
unc-110 Q18120 Outwardly rectifying K+ channel Reduced girth 71
unc-2 A0A3B1E663 Voltage-gated Ca2+ channel Reduced girth and length, abnormal axon branching, failure of left/right asymmetric neuronal fate specification 71,246,248,258
unc-7 Q03412 Gap junction Variable body width, short body length 71
unc-8 Q21974 Epithelial stretch-gated Na+ channel Reduced girth and body length, swollen ventral nerve cord 71,259
unc-9 O01393 Gap junction Small male fan, short body length, reduced girth 71
unc-17 P34711 VAChT Reduced body size and girth 246,260
unc-32 P30628 V-Type ATPase Abnormal body wall muscle morphology, pigmentation defects, small size and increased girth, abnormal pharynx, narrow rachis 71,245,246,261
unc-36 P34374 Voltage-gated Ca2+ channel Increased length, reduced girth, loss of left/right asymmetry 245,246,262
unc-38 Q23022 Ligand-gated cation channel Reduced girth and decreased body length 71
unc-49 G5ECD3 Ligand-gated Cl− channel Reduced body size 263
unc-58 Q22271 K+ two-pore domain channel Reduced body length and girth 264,265
unc-63 Q9N587 Ligand-gated cation channel Decreased body length and increased girth 71
unc-68 A0A2C9C3E8 Ca2+ release channel Reduced girth and body length, abnormal pharyngeal axons 71,266
unc-77 V6CKM5 Na+ leak channel Reduced girth, decreased body length. Abnormal vulva morphogenesis 71,267
unc-80 Q9XV66 Na+ leak channel Small eggs 268
unc-103 G5EFJ9 Voltage-gated K+ channel Reduced girth, variable body length, abnormal sarcomere morphology, abnormal body wall musculature 71,265,268
unc-105 Q09274 Epithelial Na+ channel Animals are shorter and thinner, abnormal body wall musculature, abnormal body morphology, protruding vulva 71,246,265
trpa-1 Q18297 Transient receptor potential channel Variable body length and increased girth 71
delm-1 O45402 Degenerin/epithelial Na+ channel Reduced girth and decreased body length 71
trpa-2 Q21517 Transient receptor potential channel Increased girth and decreased body length 71
acc-4 Q9U358 Ligand-gated Cl− channel Reduced girth and body length 71
asic-2 Q22851 Epithelial Na+ channel Decreased body length and increased girth 71
egas-3 Q9XTS9 Epithelial Na+ channel Abnormal body proportions 71
egas-2 Q9U1T8 Epithelial Na+ channel Reduced girth and body length 71
del-9 Q18077 Acid-sensing ion channel Abnormal body proportions 71
delm-2 P91103 Degenerin/epithelial Na+ channel Reduced girth and body length, abnormal ventral nerve cord patterning 71,269
acd-2 P91100 Degenerin/epithelial Na+ channel Reduced girth 71
del-7 Q18651 Epithelial Na+ channel Decreased body length 71
acd-5 O01664 Degenerin/epithelial Na+ channel Reduced girth and body length compared 71
asic-1 O01635 Epithelial Na+ channel Reduced girth and body length 71