Table 2.
Characteristics of standard and data-derived BMI and waist cut-offs for detection of hyperglycemia, based on the American Diabetes Association categories
| AUC | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Youden index | |
| BMI ≥25 kg/m2 | ||||||
| Women | 57.1 (52.5 to 61.7) | 79.0 (73.0 to 85.0) | 35.0 (28.0 to 43.0) | 68.0 (63.0 to 73.0) | 49.0 (40.0 to 59.0) | 0.14 |
| Men | 59.4 (52.6 to 66.2) | 64.0 (54.0 to 73.0) | 54.0 (44.0 to 64.0) | 63.0 (54.0 to 70.0) | 56.0 (45.0 to 67.0) | 0.19 |
| BMI ≥30 kg/m2 | ||||||
| Women | 57.6 (52.3 to 63.0) | 48.0 (42.0 to 54.0) | 67.0 (58.0 to 75.0) | 72.0 (64.0 to 78.0) | 43.0 (36.0 to 49.0) | 0.15 |
| Men | 58.1 (52.4 to 63.8) | 30.0 (22.0 to 38.0) | 86.0 (77.0 to 92.0) | 72.0 (57.0 to 84.0) | 51.0 (42.0 to 59.0) | 0.16 |
| BMI (data-derived) | ||||||
| Women (≥27 kg/m2) | 57.8 (52.4 to 63.2) | 63.0 (56.0 to 69.0) | 53.0 (44.0 to 61.0) | 70.0 (64.0 to 75.0) | 45.0 (37.0 to 53.0) | 0.16 |
| Men (≥24 kg/m2) | 61.9 (55.9 to 67.8) | 72.0 (64.0 to 79.0) | 51.0 (41.0 to 61.0) | 64.0 (56.0 to 71.0) | 61.0 (50.0 to 71.0) | 0.24 |
| Abdominal obesity (IDF) | ||||||
| Women (WC ≥80 cm) | 61.7 (57.3 to 66.1) | 89.0 (84.0 to 92.0) | 35.0 (27.0 to 44.0) | 70.0 (66.0 to 74.0) | 64.0 (52.0 to 74.0) | 0.24 |
| Men (WC ≥94 cm) | 62.3 (55.9 to 68.8) | 46.0 (37.0 to 56.0) | 79.0 (67.0 to 87.0) | 72.0 (61.0 to 81.0) | 55.0 (45.0 to 64.0) | 0.25 |
| Abdominal obesity (AHA/NHLBI) | ||||||
| Women (WC ≥88 cm) | 62.9 (57.6 to 68.2) | 68.0 (62.0 to 74.0) | 58.0 (50.0 to 65.0) | 74.0 (68.0 to 79.0) | 51.0 (43.0 to 59.0) | 0.26 |
| Men (WC ≥102 cm) | 57.7 (52.8 to 62.7) | 25.0 (18.0 to 33.0) | 90.0 (83.0 to 95.0) | 76.0 (59.0 to 87.0) | 50.0 (42.0 to 58.0) | 0.16 |
| Abdominal obesity (data-derived) | ||||||
| Women (WC ≥87 cm) | 63.7 (58.3 to 69.1) | 71.0 (65.0 to 77.0) | 56.0 (47.0 to 64.0) | 74.0 (68.0 to 79.0) | 53.0 (44.0 to 61.0) | 0.28 |
| Men (WC ≥86 cm) | 66.2 (59.9 to 72.6) | 74.0 (65.0 to 81.0) | 59.0 (48.0 to 69.0) | 68.0 (60.0 to 75.0) | 65.0 (54.0 to 76.0) | 0.34 |
Relevant findings using WHO categories of hyperglycemia are described in the text.
AHA, American Heart Association; AUC, area under the curve; BMI, body mass index; IDF, International Diabetes Federation; NHLBI, National Heart, Lung, and Blood Institute; NPV, negative predictive value; PPV, positive predictive value; WC, waist circumference.