Figure 3.

Kaplan–Meier analysis of estimated survival free of AoE and mitral events in patients with Marfan and Loeys–Dietz syndromes. Red curve represents patients with mitral annulus disjunction and blue curve patients without MAD. Vertical lines show multiple hash marks for multiple censoring at the same time. Left panels: patients with MAD had aortic events at younger age also in the subgroup of family members only (lower left smaller panel). AoE included acute aortic dissections and prophylactic aortic surgical interventions Right panels: mitral valve interventions were more frequent in patients with MAD, also in the subgroup of family members (lower left smaller panel). AoE, aortic events; MAD, mitral annulus disjunction.