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. 2021 Aug 13;15:329–341. doi: 10.2147/BTT.S325019

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© 2021 Xu et al.

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HHLA2 expression indicated an immune inhibitory microenvironment in the tumor nest of HCC. (A) Representative images of CD163, CD 204, CD15, and CD11b by IHC staining in HCC tissue, and the correlation between HHLA2 expression in the peri-tumor region and myeloid cell infiltration in the tumor nest of HCC (scale bar: 100 μm). **P < 0.01. (B) A heatmap shows the relationship between the expression of immune-related genes and HHLA2 in the peri-tumor region of HCC. Gene expression was normalized, and lima package was employed to acquire the differential gene expression.