Table 3.
Univariate and Multivariate Analysis of Factors Associated with Patients’ Overall Survival
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | pa | HR | 95% CI | pa | |
| Age,yr (≤50/> 50) | 0.981 | 0.660–1.459 | 0.925 | |||
| Gender (male/female) | 1.285 | 0.716–2.304 | 0.401 | |||
| HBsAg (positive/negative) | 0.966 | 0.448–2.085 | 0.930 | |||
| Cirrhosis (present/absent) | 1.264 | 0.740–2.160 | 0.391 | |||
| ALT, U/L (≥37/< 37) | 1.546 | 1.019–2.344 | 0.040 | 1.576 | 1.026–2.421 | 0.038 |
| AFP, ng/mL (> 25/≤25) | 1.735 | 1.093–2.751 | 0.019 | na | ||
| Tumor size, cm (> 5/≤5) | 1.179 | 0.748–1.8529 | 0.478 | |||
| Tumor number (multiple/single) | 1.648 | 1.105–2.457 | 0.014 | na | ||
| Vascular invasion (present/absent) | 4.849 | 3.054–7.697 | <0.001 | 3.451 | 2.068–5.760 | <0.001 |
| TNM stage (III+IV/I+II) | 2.725 | 1.829–4.060 | <0.001 | 1.978 | 1.272–3.076 | 0.002 |
| Differentiation (III+IV/I+II) | 1.089 | 0.731–1.622 | 0.646 | |||
| HHLA2 (high/low) | 1.677 | 1.117–2.518 | 0.013 | 1.872 | 1.236–2.835 | 0.003 |
Notes: Cox proportional hazards regression model; variables that were associated with overall survival in the univariate analysis were adopted as covariates in the multivariate analysis and were entered into the equation using the forward likelihood ratio method. aA Italic values indicate significance of p value (p < 0.05).
Abbreviations: AFP, alpha-fetoprotein; ALT, alanine aminotransferase; HBsAg, hepatitis B surface antigen; TNM, tumor-lymph node metastasis; CI, confidence interval; na, not applicable.