Table 3.
Association Between Genetic Variations and Types of Ischemic Stroke Risk
| Genotype | Small-Vessel Occlusion | Large-Artery | Cardioembolism | Other Type | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI)a | P value | OR (95% CI)a | P value | OR (95% CI)a | P value | OR (95% CI)a | P value | |
| rs1800587 | ||||||||
| GG | Reference | Reference | Reference | Reference | ||||
| GA | 0.59(0.29–1.21) | 0.151 | 0.93(0.50–1.74) | 0.828 | 0.89(0.31–2.57) | 0.822 | 0.76(0.40–1.44) | 0.399 |
| AA | – | – | 0.65(0.09–4.50) | 0.658 | – | – | 0.63(0.09–4.26) | 0.632 |
| GA/AA | 0.63(0.31–1.28) | 0.202 | 0.91(0.50–1.66) | 0.751 | 0.97(0.34–2.78) | 0.958 | 0.75(0.41–1.38) | 0.354 |
| Additive model | 0.70(0.36–1.37) | 0.299 | 0.89(0.53–1.54) | 0.694 | 1.06(0.40–2.82) | 0.906 | 0.77(0.45–1.33) | 0.346 |
| rs689466 | ||||||||
| TT | Reference | Reference | Reference | Reference | ||||
| CT | 2.51(1.22–5.16) | 0.012 | 0.86(0.54–1.38) | 0.535 | 1.45(0.58–3.63) | 0.432 | 1.49(0.88–2.53) | 0.138 |
| CC | 3.27(0.40–26.84) | 0.270 | 1.83(0.37–9.08) | 0.461 | 0.91(0.15–5.39) | 0.914 | 2.33(0.49–11.16) | 0.290 |
| CT/CC | 2.53(1.26–5.07) | 0.009 | 0.91(0.57–1.45) | 0.686 | 1.35(0.57–3.23) | 0.499 | 1.56(0.93–2.61) | 0.094 |
| Additive model | 2.26(1.19–4.28) | 0.013 | 0.99(0.65–1.49) | 0.941 | 1.18(0.58–2.45) | 0.641 | 1.51(0.96–2.40) | 0.078 |
| rs3918242 | ||||||||
| CC | Reference | Reference | Reference | Reference | ||||
| CT | 1.25(0.49–3.19) | 0.641 | 0.87(0.46–1.61) | 0.648 | 0.31(0.11–0.91) | 0.033 | 0.62(0.33–1.17) | 0.137 |
| TT | 0.27(0.05–1.58) | 0.146 | 2.23(0.29–25.14) | 0.517 | – | – | – | – |
| CT/TT | 1.01(0.44–2.32) | 0.987 | 0.92(0.50–1.69) | 0.790 | 0.39(0.14–1.09) | 0.072 | 0.69(0.37–1.29) | 0.239 |
| Additive model | 0.86(0.43–1.71) | 0.661 | 0.98(0.57–1.71) | 0.954 | 0.55(0.23–1.35) | 0.192 | 0.80(0.45–0.42) | 0.435 |
| rs5275 | ||||||||
| AA | Reference | Reference | Reference | Reference | ||||
| GA | 0.49(0.22–1.07) | 0.072 | 1.28(0.76–2.15) | 0.350 | 1.47(0.55–3.97) | 0.443 | 1.18(0.67–2.07) | 0.574 |
| GG | 0.31(0.12–0.80) | 0.016 | 0.97(0.50–1.88) | 0.927 | 0.83(0.24–2.95) | 0.775 | 0.54(0.27–1.10) | 0.089 |
| GA/GG | 0.45(0.21–0.95) | 0.036 | 1.20(0.74–1.93) | 0.462 | 1.20(0.49–2.96) | 0.686 | 0.96(0.57,1.61) | 0.874 |
| Additive model | 0.60(0.39–0.92) | 0.020 | 1.05(0.75–1.46) | 0.782 | 0.94(0.50–1.78) | 0.855 | 0.81(0.57,1.14) | 0.217 |
Note: aAdjusted for age, sex, smoking, and drinking; the results with a significant difference are in bold.