Table 2. Comparison of outcomes between KTx recipients with IgAN as primary disease and a matched control group of patients with non-glomerular causes of ESKD.
| Characteristic | IgAN-KTx | Matched, non-GD KTx | p- value |
|---|---|---|---|
| Median (IQR) or N (%) | Ν = 99 | Ν = 198 | |
| Ser. creatinine 1st discharge (mg/dl) | 1.53 (0.55) | 1.53 (0.66) | 0.78 |
| Estimated GFR at 1st discharge (ml/min/1.73m2) | 52 (19) | 48 (26) | 0.82 |
| Ser. creatinine 1st year (mg/dl) | 1.4 (0.5) | 1.4 (0.58) | 0.75 |
| Estimated GFR at 1st year (ml/min/1.73m2) | 52(23) | 53 (24) | 0.59 |
| Ser. creatinine end follow up (mg/dl) | 1.43 (0.64) | 1.35 (0.68) | 0.16 |
| Estimated GFR at end of follow up (ml/min/1.73m2) | 49 (22) | 52 (27) | 0.11 |
| 24-hour proteinuria 1st year (mg/day) | 154 (140) | 142.5 (139.5) | 0.20 |
| 24-hour proteinuria end follow up (mg/day) | 157 (212) | 126(154) | 0.07 |
| Acute rejection, (ever) | 11/89 (12.35) | 23/187 (12.3) | 0.99 |
| Cumulative graft loss 10 years after KTx | 6 (6.1) | 9 (4.5) | 0.55 |
| Cumulative graft loss 15 years after KTx | 10 (10.1) | 18 (9.1) | 0.76 |
| Cumulative graft loss end follow-up | 11 (11.1) | 18/196 (9.2) | 0.56 |
| Graft loss due to primary disease recurrence | 2 (2.0) | - | 0.5 |
| Graft loss due to other causes | 1(1.0) | ||
| Death (from any cause with functioning graft) | 3/88 (3.4) | 21/183 (11.5) | 0.03 |
| Alive with functioning graft (all) | 85 (85.9) | 161/195 (82.5) | 0.98 |
| Alive with functioning graft (after exclusions*) | 70/83 (84.3) | 82/108 (75.9) | 0.15 |
| Follow-up (months) | 92.7 (104) | 95.7 (110) | 0.42 |
| Primary disease recurrence in the graft | 23/99 (23.2) | - | - |
Abbreviations: IgAN; IgA nephropathy, GFR; glomerular filtration rate, ESKD; end-stage kidney disease.
*Exclusions: ABO incompatible KTx, re-transplant, non-compliance issues.