Table 3. Comparison of outcomes between KTx recipients with IgAN as primary cause of ESKD and those with other types of glomerular diseases.
| Characteristic | IgAN-KTx | LN-KTx | PIGN-KTx | IMN-KTx | FSGS-KTx |
|---|---|---|---|---|---|
| Mean (±sd), median(IQR) or N (%) | Ν = 99 | N = 22 | N = 21 | N = 19 | N = 44 |
| Ser. creatinine 1st year (mg/dl) | 1.51(0.52) | 1.42 (0.39) p = 0.44 | 1.45 (0.36) p = 0.61 | 1.58 (0.65) p = 0.60 | 1.73 (0.80) p = 0.05 |
| Estimated GFR at 1st year (ml/min/1.73 m2) | 56.0(17.6) | 56.5 (16.9) p = 0.71 | 54.15 (18.7) p = 0.66 | 48.9 (18.9) p = 0.11 | 49.9 (11.9) p = 0.0038 |
| Ser. creatinine end fup (mg/dl) | 1.55 (0.49) | 1.48 (0.3) p = 0.52 | 1.74 (0.99) p = 0.19 | 1.53 (0.76) p = 0.88 | 1.61 (0.7) p = 0.59 |
| Estimated GFR at end of fup (ml/min) | 50.5 (15.4) | 56.5 (9.9) p = 0.08 | 46.8 (11.4) p = 0.30 | 53.1 (20.9) p = 0.52 | 51.6 (20.9) p = 0.61 |
| 24h proteinuria 1st year (mg/day) | 154(140) | 199.5 (187.5) p = 0.54 | 110 (93) p = 0.054 | 209 (600) p = 0.07 | 585.5 (2875) p = 0.0008 |
| 24h proteinuria end fup (mg/day) | 157 (212) | 60.5 (442) p = 0.18 | 275(455) p = 0.12 | 184(243) p = 0.47 | 1250 (5608) p = 0.0001 |
| Primary disease recurrence (graft) | 23 (23.2) | 0 p = 0.01 | 0 p = 0.01 | 8 (42.1) p = 0.17 | 26 (59.1)) p<0.0001 |
| Acute rejection, (ever) | 11 (11.1) | 1 (4.5) p = 0.35 | 1 (4.7) p = 0.33 | 3 (9.5) p = 0.83 | 3 (6.8) p = 0.42 |
| Cumulative graft loss end fup | 11 (11.1) | 3 (13.6) p = 0.74 | 2 (9.5) p = 0.81 | 3 (14.2) p = 0.77 | 9 (20.45) p = 0.13 |
| Graft loss due to primary disease recurrence | 2 (2.0) | 0 p = 0.55 | 0 p = 0.53 | 0 p = 0.5 | 5 (11.4) p = 0.0165 |
| Alive with functioning graft | 85 (85.9) | 18 (81.8) p = 0.62 | 17 (80.95) p = 0.56 | 18 (85.7) p = 0.98 | 34 (77.2) p = 0.2 |
| Follow-up (months) | 103.4 (60.9) | 80.2 (56.7) p = 0.087 | 81.2 (50.1) p = 0.1 | 72.9 (38.7) p = 0.032 | 64.95 (50.7) p = 0.0003 |
Abbreviations: IgAN; IgA nephropathy, FSGS; focal segmental glomerulosclerosis, IMN; idiopathic membranous nephropathy, LN; lupus nephropathy, PIGN; pauci-immune glomerulonephritis, ESKD; end-stage kidney disease, GFR; glomerular filtration rate.
Comparisons between the IgAN-KTx group versus all other groups of KTx recipients is depicted by presenting the p-value (p) in each category separately.