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. 2021 Aug 17;16(8):e0252781. doi: 10.1371/journal.pone.0252781

Table 3. Differences in selecting symptom items of the DN4 questionnaire between the NCP (N = 722) and non-NCP (N = 1,281) groups.

DN4 Symptom items Total NCP Non-NCP Univariable Multivariable*
N = 2,003(%) N = 722 (%) N = 1,281 (%) Crude OR (95% CI) Adjusted OR (95% CI) Pseudo R2**
Burning 312 (15.6) 198 (63.5) 114 (36.5) 3.87 (3.01–4.98) 3.86 (3.00–4.97) 0.088
Painful Cold 450 (22.5) 345 (76.7) 105 (23.3) 10.25 (8.00–13.13) 10.51 (8.18–13.48) 0.265
Electric shocks 1,069 (53.4) 632 (59.1) 437 (40.9) 13.56 (10.57–17.40) 13.35 (10.40–17.14) 0.348
Tingling 1,114 (55.6) 638 (57.3) 476 (42.7) 12.85 (9.96–16.56) 12.69 (9.84–16.37) 0.330
Pins and Needles 844 (42.1) 471 (55.8) 373 (44.2) 4.57 (3.76–5.55) 4.53 (3.72–5.51) 0.168
Numbness 512 (25.6) 398 (77.7) 114 (22.3) 12.58 (9.87–16.02) 12.57 (9.86–16.03) 0.318
Itching 328 (16.4) 220 (67.1) 108 (32.9) 4.76 (3.70–6.13) 4.64 (3.60–5.98) 0.111
Touch hypoesthesia 524 (26.2) 436 (83.2) 88 (16.8) 20.67 (15.89–26.88) 20.56 (15.79–26.78) 0.405
Prick hypoesthesia 213 (10.6) 200 (93.9) 13 (6.1) 37.37 (21.13–66.09) 36.95 (20.88–65.38) 0.233
Hyperesthesia 238 (11.9) 189 (79.4) 49 (20.6) 8.92 (6.41–12.40) 8.75 (6.29–12.19) 0.147

Chi-square tests, all statistically significant, P<0.001.

*Age- and sex-adjusted

**Negelkerke R2.

CI: Confidence interval; NCP: Neuropathic cancer pain; OR: Odds ratio.