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. 2021 Aug 5;17(8):e1009848. doi: 10.1371/journal.ppat.1009848

Fig 3. Inhibition of HSV-1 replication by gK4 peptide in vitro.

Fig 3

Vero cells were infected with 0.1 PFU/cell of HSV-1 strain McKrae in the presence of 10, 20, 30, 40, or 50 μg/ml of dTat-gK4 peptide or control dTat peptide for 1 hr. After 1hr infection, the media was replaced with fresh media containing each peptide. Infected cells were harvested 24 hr PI and virus titer was measured by standard plaque assay. Virus replication was significantly inhibited by dTat-gK4 peptide in a dose dependent manner. Half maximal effective concentration (EC 50) of dTat-gK4 peptide was around 2.1 μM (6.6 μg/ml).