Table 5.
List of companies working on translational research on gut microbiome, location and their research focus
| Company | Location | Research focus |
|---|---|---|
| Adapsyn Bioscience | Canada | Production of novel bacterial metabolites |
| AOBiome | Boston | Restoration of ammonia oxidizing bacteria |
| A-Mansia | Louvain-la-Neuve | microbial products based on unique properties of the Akkermansia muciniphila bacterium |
| ActoBio Therapeutics | Ghent | Targeted and microbe-based therapeutic agents for locally delivering potential disease modifying therapeutics |
| 4D Pharma | UK | Novel therapeutics |
| Artugen Therapeutics | Concord | Novel Live Biotherapeutic Products to help patients living with infectious, inflammatory and oncologic diseases |
| Biohm | Cleveland | Probiotic comprising bacteria, fungi and enzymes to remove digestive plaques |
| BioGaia | Stockholm | Developing probiotics for gut and immune system |
| BioMe | Oslo | High-throughput microbiome analysis and probiotic development |
| Biomica | Park Rehovot | Microbiome-based therapeutics for the treatment of immune-mediated and infectious diseases, with specific focus on Immuno-Oncology and GI-related disorders |
| BiomX | Ness Ziona | Phage cocktails containing natural and/or engineered phage developed through algorithm and experimental validation for targeted killing of specific pathogenic bacteria |
| Biosortia Pharmaceuticals | San Diego | Development of drugs/therapeutics based on the cell to cell communication chemistry from mining of microbiome in the field of immuno-oncology and immunology |
| Boehringer Ingelheim | Fremont | Small Molecules, Biologics, Microbiome |
| Carverr | Brooklyn | Developing traceable probiotics and custom microbiomes |
| CHAIN Biotechnology | Nottingham, Marlow | Develop live biotherapeutics—these are novel drugs based on living bacteria found in the gut but engineered to deliver specific therapeutic molecules |
| ClostraBio | Chicago | Developing new therapeutics to treat food allergies and provide protective immunity |
| Consortia Therapeutics | La Jolla CA | Develops microbial therapies to prevent and treat human disease and allergies |
| Da Volterra | Paris | Development of microbiota protective therapy during antibiotic treatments to help prevent and cure human diseases |
| Diagnostic Solutions Laboratory | Alpharetta | Provides diagnostic solutions for identifying pathogenic organisms in stool through PCR and comprehensive stool testing for assessing GI health through DNA-based studies |
| EnteroBiotix | UK | Full therapeutic potential of fecal microbiota transplantation (FMT) through a field-leading GMP-compliant minimally manipulated microbiome platform and an ex vivo microbiome engineering platform |
| Enterome | Cambridge and Paris | Discovery and development of novel therapeutics upon understanding the gut microbe and immune system interaction; production of small molecules and peptides with a focus on cancer, autoimmune, inflammatory and metabolic diseases |
| Evolve Biosystems | Davis | Developing the next generation of products to establish, restore and maintain a healthy newborn gut microbiome |
| Federation Bio | South San Francisco | Therapeutic approaches of using beneficial microbes for curing human diseases like secondary hyperoxaluria, metabolic disorders, cancer, immune diseases |
| Finch Therapeutics | Somerville MA | Developing oral microbiome drugs for recurrent C. difficile, chronic hepatitis B, inflammatory bowel disease and children with autism and significant GI symptoms |
| Gusto Global | Morrisville NC | Development of novel live biotherapeutic products through advanced computational and microbiological tools for targeted immune modulation and optimization of metabolic pathways |
| Kaleido Biosciences | Bedford MA | Develop microbial metabolic therapies (MMT) to understand the disease pathways, such as the use of synthetic glycans, harnessing target enzymes across the microbial taxa, formulation of therapeutic products to mitigate serious complications of Covid-19, treat IBD, urea cycle disorders and hepatic encephalopathy |
| Locus Biosciences | Morrisville NC | Works on CRISPR-Phage (crPhage) platform combines the antibacterial power of CRISPR-Cas3 with the efficient, safe delivery of bacterial viruses called bacteriophage. The lead targets are E. coli, Clostridium difficile and organisms causing respiratory infections |
| MaaT | France | Patient specific biotherapeutics for improving the survival outcome of blood cancer through proprietary data collection and analysis on CGMP platform |
| Metabiomics | Aurora CO, Manassas VA, Chevy Chase MD; US | Developing a non-invasive microbiome test for the earlier and more accurate detection of colon polyps and colorectal cancer |
| Microbiotica Limited | Cambridge, UK | Identifies gut bacteria linked to phenotype with unprecedented precision in order to discover and develop live bacterial therapeutics and biomarkers |
| Novome Biotechnologies | South San Francisco CA; United States | Synthetic biology and microbial therapies; selecting potential bacteria from the human gut microbiome, engineering them to express therapeutic products to treat chronic disease |
| Oragenics | Florida, US | Production of lantibiotics helpful to recover microbial antibiotic resistance and prebiotics active in weight management in obese people |
| TargEDys | Rouen; France | Appetite regulation via molecular mimicry of pharmacological targets controlling gut brain axis involving bacterial, hormonal mimetic, proteins naturally occurring in the gut microbiome. They target to regulate/ moderate appetite in obese and/or old aged people |
| Sun Genomics | San Diego CA, USA | Customises probiotics constituting gut microbes, such as Lactobacillus acidophillus, L. rhamnosus, Bifidobacterium lactis |
| Synlogic | Cambridge, MA | Develop biotic medicines to treat various metabolic diseases like phenylketonuria, hyperoxaluria as well as immunomodulation therapies to treat diseases like cancer, IBS, etc |
| Sugarlogix | Berkeley CA, USA | Produces complex sugars with prebiotic functions which selectively feed the beneficial human gut bacteria strengthening the immune and nervous functions in turn |
| Seres Therapeutics | Cambridge, MA | Formulates and develops microbiome therapeutics to cure recurrent C. difficile, ulcerative colitis, metastatic melanoma and antibiotic resistant bacterial disease and graft versus host disease, |
| Vedanta BioSciences | Cambridge MA, United States | Leveraging live therapeutics made up of gut bacterial consortia which can stimulate immunoregulatory responses controlling allergic diseases as well as holds roles in cancer and vaccination |
| Xeno Biosciences | Los Angeles CA, United States | Engineer gut bacterial consortia addressing obesity and metabolism-related diseases; oral formulation of probiotic composition to cause weight loss by mimicking the microbiome changes induced by gastric bypass surgery |