FIG 7.
Neonatal EPEC infection caused impaired intestinal physiology in adulthood. (A to C) Ussing chambers were used to assess the secretory state (short-circuit current [Isc]) (A) and tight junction permeability via conductance (G) (B) and FITC-dextran flux (C) in both the ileum and colon. (D) Histology of ileum (left) and colon (right) with representative H&E staining. (E) Relative mRNA expression in the ileum and colon (n = 12 to 16 mice per group) (*, P ≤ 0.05; **, P ≤ 0.01; ***, P < 0.001 [by Student’s t test, with a Mann-Whitney test and Welch’s correction where appropriate]).